Wow ... that was stunning
I never thought I could enjoy that much a sprite animation. It was simply incredible. The storyline itself was interesting and cool to follow as the many references to video games were good. But definitely, I have to say the fight scenes were fucking amazing. It truly was better than most stuff I've seen even from the greatest frame-by-frame artists. It just kept me breathless ... truly amazing.
The sprites were used perfectly, it just looked great. The style was pretty awesome, even though that kind of story has been used before, this one had taste and kept our interest all along. The sound effects and the music did fit pretty good, in fact it really added to the animation and contributed to make it better, I especially liked your pick for the final fight, the Rockman Neo's song is very dynamic, exactly what you needed. Violence, interactivity and humor wasn't really the point of your animation, but still the fight looked very nasty, I give you the highest mark for non-bloody violence.
Overall it's definitely the best sprite animation I've ever seen, it was a fine piece of work, it made my day and made its way to my personal favorites.